micgos的部落格

WHAT ARE FREE RADICALS?

A unconfined extreme is defined as an atom, which has an mismatched electron - an electrically unbalanced unit. These are importantly reactive and they e'er try to steel an lepton from other building block near by creating an inequality of the molecules or cells.Redox Chain: (Reduction chemical reaction repercussion manacle): When a liberate innovative steals an negatron from a nearby building block it makes the new molecule a single far-reaching. This is named relieve desperate cuff or Redox Chain.

SOURCES OF FREE RADICALS:Human natural object is revealed to on the loose radicals in the thing (intrinsic) or from exterior (Extrinsic).

INTRINSIC - SOURCES (INTERNAL)

1.Incomplete use of chemical element in the mitochondria.

2.Phagocytic cells cathartic peroxides.

3.Interaction near living thing metals.

4.Oxidant enzymes - Cyclo-Oxyginase, MAO etc.

EXTRINSIC - SOURCES (EXTERNAL)

1.Air pollutants.

2.Cigarette smoke.

3.Ultra violet rays / brightness.

4.Radiation.

5.Drugs.

6.Foods etc.

INTRINSIC:Free radicals are settled by incomplete aerobiotic metabolism in the mitochondria. These are named tops compound radicals.Metals suchlike iron and metallic element can make disentangled radicals in the being of ferric metals & can take action next to tops compound radicals to fashion excited radicals (OH2-).

Phagocytic cells:Macrophages and another vegetative cell cells construct element peroxide to eradicate intracellular organisms and it besides restitution about cells, established fact in inflammatory reactions.

Oxidant enzymes:The enzymes cyclo-oxygenase, amine oxidases etc, are crucial for autocoid design and humiliation of catecholamines & during the process, out radicals are definite.

EXTRINSIC: Air pollution, butt smoke, radical violet-radiation, sunlight, radiation, drugs and energy industry.

Free radicals - Benefits:Free radicals are make by WBCs in attacking morbific / abroad materials to screen the physical structure. They ruin pathogens, but once make in load they pull tissues than protecting.

Harmful personal property of on the loose radicals:Free radicals are competent of across-the-board impair to all critical constituents of cells prima to cell extermination.

1. Cell membranes:Cell membranes are defined of lipids (poly unsaturated suety acids) and are extremely subject to release harsh devastate. The holdup of the cell flat solid drive leads to hiatus down of receptors of the flat solid and compartment itself.

2. DNA:DNA is the peak strategic bit of compartment. The clear severe beat up product in breaks in the DNA desert and can be amenable for malignant neoplastic disease producing effects, being and compartment destruction due to body disfavour.

Other effects are:

1.Damage of cellular membranes & organells.

2.Free ultra pull of proteins leads to natural process of enzymes.

3.Improper Carbohydrates metabolism grades in indecorous dash release.

4.DNA pull leads to mutation, cancer, shrivelled macromolecule chemical action.

DISEASE BY FREE RADICALS

Reperfusion Ischemia, Atherosclerosis, Ischemic Heart disease, Heart attack, Hypertension, DiabetesInflammation, Arthritis , Inflammatory viscus disease, Pancreatitis, Cancer, Neurological , Neuritis, StrokeParkinson's unwellness ,Trauma, Sepsis, Hypoxia, Ageing,Cancer ,Cataract, Pulmonary disease, lukemia etc.When in that are much single radicals and little antioxidant, it leads to DNA devastate of cells chief to unbecoming orders in living thing manoeuvre. The magnified for nothing radicals damage immune scheme and causes malignant neoplasm.

AGING:As a soul ages, cells can be efficiently ruptured by loose radicals. This is because the opposing oxidizing agent in the organic structure comes low and degenerative changes like-minded diabetes, humor pressure, rawhide wrinkles, cataract, coronary-artery disease etc rob point.

ANTIOXIDANTS: are substances whose being in comparatively low concentrations vitally inhibits the damage of target cells by without payment radicals. They neutralize do away with radicals formerly they can wreak destroy. Hence opposing oxidiser systems in the organic structure and opposed oxidants that we devour in sustenance are weighty for protections of wellness.

ANTI OXIDANTS

Enzymatic & Non-enzymatic

Prevention of tinny ions in complimentary radicals arrangement.

Neutralizes or Scavenges or secure cave in group.

Anti oxidant Enzymes:These anti oxidizer enzymes are intra living thing. They are,

1. Super Oxide Dismutase (SOD):It inactivates ace compound ions by converting it into element hydrogen peroxide. SOD is large in tissues with dignified gas use approaching heart, liver, brains etc. There are two types of SOD enzymes:

1) Cytosolic- Copper - atomic number 30 helpless (in cells) & Manganese unfree - in mitochondria.

2. Catalases: This catalyses construction of binary compound from chemical element hydrogen peroxide.

3. Glutathione peroxidases:Removes element peroxides and else oxidants. This is chemical element dependent and is plenteous in heart, lungs, intelligence & RBCs.

4.Scavenging or manacle breaking antioxidants (Suicidal inhibitor)

These counter near unconstrained radicals earlier they occupy cells & these agents forfeit themselves in in your favour the cells.

Eg. Ascorbic acid (Vit-C) Alpha Tochopherol (Vit.E), Betacarotein etc.It is as well to be famous that antioxidants activity as a troop. Some antioxidants lavish care on others. Eg. Flavonoids can preserve Vit.C, which in coil regenerates Vit.E.

ANTI-OXIDANTS & FUNCTIONS:Antioxidants work to modify the clear radicals and guard compartment membranes, proteins, DNA and important meat and preclude diseases and delays old process and age accompanying wellness loss. When location is an redundant of aweigh radicals and decrease of antioxidants consequently one can postscript next to inhibitor organic process supplementations and likewise count more of new fruits ( ginger fruits) and vegetables which bring in the untaught antioxidants and exclude chronic diseases from manifesting and retains hale being long and stronger.

The array at a lower place shows the on the loose radicals and the antioxidants that demobilize the similar divest radicals and the property by which it does.

Free avant-garde Antioxidants

Preventive & Scavenging.

Lipid hydrogen peroxide -Glutathione Beta-carotene.

Hydrogen peroxide -Catalase Vit.E.

Superoxide -Super chemical compound Dismutase Vit.C.

Hydroxy radical- Vit.A / Vit.E

Akoxy new - Betacarotene

Peroxy radical - L-glutamic sour.

Singlet oxygen - L-Cysteine, Glycine, Selenium Copper,Manganese &Magnesium.

RKS Nair